Publications of our Bo&MeRanG-Students

2020

Lisa Assmus

Namineni S, O‘Connor T, Faure-Dupuy S, Johansen P, Riedl T, Liu K, Xu H, Singh I, Shinde P, Li F, Pandyra A, Sharma P, Ringelhan M, Muschaweckh A, Borst K, Blank P, Lampl S, Durantel D, Farhat R, Weber A, Lenggenhager D, Kündig TM, Staeheli P, Protzer U, Wohlleber D, Holzmann B, Binder M, Breuhahn K, Assmus LM, Nattermann J, Abdullah Z, Rolland M, Dejardin E, Lang PA, Lang KS, Karin M, Lucifora J, Kalinke U, Knolle PA, Heikenwalder M. A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control. J. Hepatol. 2020;S0168827820300106.

Patrick Günther

Warnat-Herresthal S, Perrakis K, Taschler B, Becker M, Baßler K, Beyer M, Günther P, Schulte-Schrepping J, Seep L, Klee K, Ulas T, Haferlach T, Mukherjee S, Schultze JL. Scalable Prediction of Acute Myeloid Leukemia Using High-Dimensional Machine Learning and Blood Transcriptomics. iScience 2020;23(1):100780.

Sebastian Liene

Vasanthakumar A, Chisanga D, Blume J, Gloury R, Britt K, Henstridge DC, Zhan Y, Valle Torres S, Liene S, Collins N, Cao E, Sidwell T, Li C, Spallanzani RG, Liao Y, Beavis PA, Gebhardt T, Trevaskis N, Nutt SL, Zajac JD, Davey RA, Febbraio MA, Mathis D, Shi W, Kallies A. Sex-specific adipose tissue imprinting of regulatory T cells. Nature 2020;579:581-585

Marcel Michla

Karagiannis F, Masouleh SK, Wunderling K, Surendar J, Schmitt V, Kazakov A, Michla M, Hölzel M, Thiele C, Wilhelm C. Lipid-Droplet Formation Drives Pathogenic Group 2 Innate Lymphoid Cells in Airway Inflammation. Immunity. April2020;S1074761320301163

Marie-Sophie Philipp

Enders M*, Franken L*, Philipp MS*, Kessler N*, Baumgart AK, Eichler M, Wiertz EJH, Garbi N*, Kurts C*. Splenic Red Pulp Macrophages Cross-Prime Early Effector CTL That Provide Rapid Defense against Viral Infections. J. Immunol. 2020;204(1):87–10

Marc Rigau

Rigau M, Ostrouska S, Fulford TS, Johnson DN, Woods K, Ruan Z, McWilliam HEG, Hudson C, Tutuka C, Wheatley AK, Kent SJ, Villadangos JA, Pal B, Kurts C, Simmonds J, Pelzing M, Nash AD, Hammet A, Verhagen AM, Vairo G, Maraskovsky E, Panousis C, Gherardin NA, Cebon J, Godfrey DI, Behren A, Uldrich AP. Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells. Science 2020;eaay5516.

Santiago Valle Torres

Vasanthakumar A, Chisanga D, Blume J, Gloury R, Britt K, Henstridge DC, Zhan Y, Valle Torres S, Liene S, Collins N, Cao E, Sidwell T, Li C, Spallanzani RG, Liao Y, Beavis PA, Gebhardt T, Trevaskis N, Nutt SL, Zajac JD, Davey RA, Febbraio MA, Mathis D, Shi W, Kallies A. Sex-specific adipose tissue imprinting of regulatory T cells. Nature 2020;579:581-585.

Alessandra Webers

Webers A, Heneka MT, Gleeson PA. The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer’s disease. Immunol. Cell Biol. 2020;98(1):28–41.

 

  

2019

Sabrina Dähling

Bachem A, Makhlouf C, Binger KJ, de Souza DP, Tull D, Hochheiser K, Whitney PG, Fernandez-Ruiz D, Dahling S, Kastenmuller W, Jonsson J, Gressier E, Lew AM, Perdomo C, Kupz A, Figgett W, Mackay F, Oleshansky M, Russ BE, Parish IA, Kallies A, McConville MJ, Turner SJ, Gebhardt T, and Bedoui S. Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8(+) T Cells. Immunity. 2019.

Ioanna Gemünd

Kapellos TS, Bonaguro L, Gemünd I, Reusch N, Saglam A, Hinkley ER, Schultze JL. Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases. Front. Immunol. 2019;10:2035.

Elise Gressier

Bachem A, Makhlouf C, Binger KJ, de Souza DP, Tull D, Hochheiser K, Whitney PG, Fernandez-Ruiz D, Dahling S, Kastenmuller W, Jonsson J, Gressier E, Lew AM, Perdomo C, Kupz A, Figgett W, Mackay F, Oleshansky M, Russ BE, Parish IA, Kallies A, McConville MJ, Turner SJ, Gebhardt T, and Bedoui S. Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8(+) T Cells. Immunity. 2019.

Patrick Günther

1.) Bassler K, Günther P, Schulte-Schrepping J, Becker M, and Biernat P. A Bioinformatic Toolkit for Single-Cell mRNA Analysis. Methods in molecular biology. 2019;1979(433-55.

2.) Günther P, Schultze JL. Mind the Map: Technology Shapes the Myeloid Cell Space. Front. Immunol. 2019;10:2287.

3.) Camell CD, Günther P, Lee A, Goldberg EL, Spadaro O, Youm Y-H, Bartke A, Hubbard GB, Ikeno Y, Ruddle NH, Schultze J, Dixit VD. Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis. Cell Metab. 2019;30(6):1024-1039.e6.

Marie-Sophie Philipp 

Kelly J, Minoda Y, Meredith T, Cameron G, Philipp MS, Pellicci DG, Corbett AJ, Kurts C, Gray DH, Godfrey DI, Kannourakis G, and Berzins SP. Chronically stimulated human MAIT cells are unexpectedly potent IL-13 producers. Immunology and cell biology. 2019.

Anastasia Solomatina

Ng GZ, Solomatina A, van Driel IR, and Hartland EL. The Mouse as a Model for Pulmonary Legionella Infection. Methods in molecular biology. 2019;1921(399-417.

Maike Effern

1.) Ralser DJ, Takeuchi H, Fritz G, Basmanav FB, Effern M, Sivalingam S, El-Shabrawi-Caelen L, Degirmentepe EN, Kocaturk E, Singh M, Booken N, Spierings NMK, Schnabel V, Heineke A, Knuever J, Wolf S, Wehner M, Tronnier M, Leverkus M, Tantcheva-Poor I, Wenzel J, Oji V, Has C, Holzel M, Frank J, Haltiwanger RS, and Betz RC. Altered Notch Signaling in Dowling-Degos Disease: Additional Mutations in POGLUT1 and Further Insights into Disease Pathogenesis. The Journal of investigative dermatology. 2019;139(4):960-4.

2.) Li X-Y, Moesta AK, Xiao C, Nakamura K, Casey M, Zhang H, Madore J, Lepletier A, Aguilera AR, Sundarrajan A, Jacoberger-Foissac C, Wong C, Dela Cruz T, Welch M, Lerner AG, Spatola BN, Soros VB, Corbin J, Anderson AC, Effern M, Hölzel M, Robson SC, Johnston RL, Waddell N, Smith C, Bald T, Geetha N, Beers C, Teng MWL, Smyth MJ. Targeting CD39 in Cancer Reveals an Extracellular ATP- and Inflammasome-Driven Tumor Immunity. Cancer Discov. 2019;9(12):1754–1773.

3.) Park SL, Buzzai A, Rautela J, Hor JL, Hochheiser K, Effern M, McBain N, Wagner T, Edwards J, McConville R, Wilmott JS, Scolyer RA, Tuting T, Palendira U, Gyorki D, Mueller SN, Huntington ND, Bedoui S, Holzel M, Mackay LK*, Waithman J*, and Gebhardt T*. Tissue-resident memory CD8(+) T cells promote melanoma-immune equilibrium in skin. Nature. 2019;565(7739):366-71.

Markus Fleischmann

Anderson BM, Poole DP, Aurelio L, Ng GZ, Fleischmann M, Kasperkiewicz P, Morissette C, Drag M, van Driel IR, Schmidt BL, Vanner SJ, Bunnett NW, Edgington-Mitchell LE. Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease. Sci. Rep. 2019;9(1):13295.

  

2018

Patrick Günther

Christ A, Gunther P, Lauterbach MAR, Duewell P, Biswas D, Pelka K, Scholz CJ, Oosting M, Haendler K, Bassler K, Klee K, Schulte-Schrepping J, Ulas T, Moorlag S, Kumar V, Park MH, Joosten LAB, Groh LA, Riksen NP, Espevik T, Schlitzer A, Li Y, Fitzgerald ML, Netea MG, Schultze JL, Latz E (2018) Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming. Cell 172: 162-175 e114

Annemarie Steiner

1.)Davidson S, Steiner A, Harapas CR, Masters SL (2018) An Update on Autoinflammatory Diseases: Interferonopathies. Current rheumatology reports 20: 38

2.) Harapas CR, Steiner A, Davidson S, Masters SL (2018) An Update on Autoinflammatory Diseases: Inflammasomopathies. Current rheumatology reports 20: 40

3.) Steiner A, Harapas CR, Masters SL, Davidson S (2018) An Update on Autoinflammatory Diseases: Relopathies. Current rheumatology reports 20: 39

Anna Belen Erazo

1.) Fulle L, Steiner N, Funke M, Gondorf F, Pfeiffer F, Siegl J, Opitz FV, Hassel SK, Erazo AB, Schanz O, Stunden HJ, Blank M, Grober C, Handler K, Beyer M, Weighardt H, Latz E, Schultze JL, Mayer G, Forster I (2018) RNA Aptamers Recognizing Murine CCL17 Inhibit T Cell Chemotaxis and Reduce Contact Hypersensitivity In Vivo. Molecular therapy : the journal of the American Society of Gene Therapy 26: 95-104

2.) Fulle L, Offermann N, Hansen JN, Breithausen B, Erazo AB, Schanz O, Radau L, Gondorf F, Knopper K, Alferink J, Abdullah Z, Neumann H, Weighardt H, Henneberger C, Halle A, and Forster I. CCL17 exerts a neuroimmune modulatory function and is expressed in hippocampal neurons. Glia. 2018;66(10):2246-61.

Elise Gressier

Whitney PG, Makhlouf C, MacLeod B, Ma JZ, Gressier E, Greyer M, Hochheiser K, Bachem A, Zaid A, Voehringer D, Heath WR, Wagle MV, Parish I, Russell TA, Smith SA, Tscharke DC, Gebhardt T, Bedoui S (2018) Effective Priming of Herpes Simplex Virus-Specific CD8(+) T Cells In Vivo Does Not Require Infected Dendritic Cells. Journal of virology 92: 

Jonas Möcking

Yu CH, Moecking J, Geyer M, Masters SL (2018) Mechanisms of NLRP1-Mediated Autoinflammatory Disease in Humans and Mice. Journal of molecular biology 430: 142-152

 

2017

Alessandra Webers

Ardura-Fabregat A, Boddeke E, Boza-Serrano A, Brioschi S, Castro-Gomez S, Ceyzeriat K, Dansokho C, Dierkes T, Gelders G, Heneka MT, Hoeijmakers L, Hoffmann A, Iaccarino L, Jahnert S, Kuhbandner K, Landreth G, Lonnemann N, Loschmann PA, McManus RM, Paulus A, Reemst K, Sanchez-Caro JM, Tiberi A, Van der Perren A, Vautheny A, Venegas C, Webers A, Weydt P, Wijasa TS, Xiang X, Yang Y (2017) Targeting Neuroinflammation to Treat Alzheimer's Disease. CNS drugs 31: 1057-1082

Sabrina Dähling

Brewitz A, Eickhoff S, Dahling S, Quast T, Bedoui S, Kroczek RA, Kurts C, Garbi N, Barchet W, Iannacone M, Klauschen F, Kolanus W, Kaisho T, Colonna M, Germain RN, Kastenmuller W (2017) CD8(+) T Cells Orchestrate pDC-XCR1(+) Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming. Immunity 46: 205-219

Maike Effern

1.) Falletta P, Sanchez-Del-Campo L, Chauhan J, Effern M, Kenyon A, Kershaw CJ, Siddaway R, Lisle R, Freter R, Daniels MJ, Lu X, Tuting T, Middleton M, Buffa FM, Willis AE, Pavitt G, Ronai ZA, Sauka-Spengler T, Holzel M, Goding CR (2017) Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma. Genes & development 31: 18-33

2.) Layer JP, Kronmuller MT, Quast T, van den Boorn-Konijnenberg D, Effern M, Hinze D, Althoff K, Schramm A, Westermann F, Peifer M, Hartmann G, Tuting T, Kolanus W, Fischer M, Schulte J, Holzel M (2017) Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression. Oncoimmunology 6: e1320626

Matthias Enders

Fernandez-Ruiz D, Lau LS, Ghazanfari N, Jones CM, Ng WY, Davey GM, Berthold D, Holz L, Kato Y, Enders MH, Bayarsaikhan G, Hendriks SH, Lansink LIM, Engel JA, Soon MSF, James KR, Cozijnsen A, Mollard V, Uboldi AD, Tonkin CJ, de Koning-Ward TF, Gilson PR, Kaisho T, Haque A, Crabb BS, Carbone FR, McFadden GI, Heath WR (2017) Development of a Novel CD4(+) TCR Transgenic Line That Reveals a Dominant Role for CD8(+) Dendritic Cells and CD40 Signaling in the Generation of Helper and CTL Responses to Blood-Stage Malaria. J Immunol 199: 4165-4179

Lisa Assmus

Hackstein CP, Assmus LM, Welz M, Klein S, Schwandt T, Schultze J, Forster I, Gondorf F, Beyer M, Kroy D, Kurts C, Trebicka J, Kastenmuller W, Knolle PA, Abdullah Z (2017) Gut microbial translocation corrupts myeloid cell function to control bacterial infection during liver cirrhosis. Gut 66: 507-518

Marie Sophie Philipp

Heuser C, Gotot J, Piotrowski EC, Philipp MS, Courreges CJF, Otte MS, Guo L, Schmid-Burgk JL, Hornung V, Heine A, Knolle PA, Garbi N, Serfling E, Evaristo C, Thaiss F, Kurts C (2017) Prolonged IKKbeta Inhibition Improves Ongoing CTL Antitumor Responses by Incapacitating Regulatory T Cells. Cell Rep 21: 578-586    

Patrick Günther

1.) Sander J, Schmidt SV, Cirovic B, McGovern N, Papantonopoulou O, Hardt AL, Aschenbrenner AC, Kreer C, Quast T, Xu AM, Schmidleithner LM, Theis H, Thi Huong LD, Sumatoh HRB, Lauterbach MAR, Schulte-Schrepping J, Gunther P, Xue J, Bassler K, Ulas T, Klee K, Katzmarski N, Herresthal S, Krebs W, Martin B, Latz E, Handler K, Kraut M, Kolanus W, Beyer M, Falk CS, Wiegmann B, Burgdorf S, Melosh NA, Newell EW, Ginhoux F, Schlitzer A, Schultze JL (2017) Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2. Immunity 47: 1051-1066 e1012

2.) See P, Dutertre CA, Chen J, Gunther P, McGovern N, Irac SE, Gunawan M, Beyer M, Handler K, Duan K, Sumatoh HRB, Ruffin N, Jouve M, Gea-Mallorqui E, Hennekam RCM, Lim T, Yip CC, Wen M, Malleret B, Low I, Shadan NB, Fen CFS, Tay A, Lum J, Zolezzi F, Larbi A, Poidinger M, Chan JKY, Chen Q, Renia L, Haniffa M, Benaroch P, Schlitzer A, Schultze JL, Newell EW, Ginhoux F (2017) Mapping the human DC lineage through the integration of high-dimensional techniques. Science 356

 

2016

Christina Budden

Hoss F, Budden CF, Latz E (2016) IRGB10 Exposes Bacteria's Intimate Secrets. Developmental cell 39: 7-8

Patrick Günther

1.) Mass E, Ballesteros I, Farlik M, Halbritter F, Gunther P, Crozet L, Jacome-Galarza CE, Handler K, Klughammer J, Kobayashi Y, Gomez-Perdiguero E, Schultze JL, Beyer M, Bock C, Geissmann F (2016) Specification of tissue-resident macrophages during organogenesis. Science 353

2.) Schmidt SV, Krebs W, Ulas T, Xue J, Bassler K, Gunther P, Hardt AL, Schultze H, Sander J, Klee K, Theis H, Kraut M, Beyer M, Schultze JL (2016) The transcriptional regulator network of human inflammatory macrophages is defined by open chromatin. Cell research 26: 151-170

3.) Shahbazi E, Moradi S, Nemati S, Satarian L, Basiri M, Gourabi H, Zare Mehrjardi N, Gunther P, Lampert A, Handler K, Hatay FF, Schmidt D, Molcanyi M, Hescheler J, Schultze JL, Saric T, Baharvand H (2016) Conversion of Human Fibroblasts to Stably Self-Renewing Neural Stem Cells with a Single Zinc-Finger Transcription Factor. Stem cell reports 6: 539-551